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According to the leaky gut theory, these alterations in gut microbiota may be related to inadequate perfusion to the viscera due to cardiac congestion or impaired ejection capacity in patients with HF, and ischemic edema in the intestine caused by ischemia, which might increase the permeability of the intestinal epithelium (Sandek et al., 2007), thus allowing intestinal macrobiotic and bacterial metabolites to gain access to the circulatory system through the compromised barrier

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For example, when hepatocytes are depleted of cholesterol, SCAP transports SREBP from the ER to the Golgi, where two proteases, Site-1 protease and Site-2 protease act in sequence to release the NH the ER to the Golgi, where two proteases, Site-1 protease and Site-2 protease act in sequence to release the NH 2 terminal of SREBP from the membrane (see also Fig

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