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Further validation arises from ex vivo assessments, revealing curcumins proficiency in curbing RGC loss through the suppression of MAPK, caspase-9, and caspase-3 pathways in murine optic nerves [460]

J Biol Chem 254:49824992 Cooper AJ (2012) The role of glutamine synthetase and glutamate dehydrogenase in cerebral ammonia homeostasis

The presence of terminal surface silanol (SiOH) groups allows facile covalent modification by organic ligands, polymers, and biomolecules, transforming MSNs into multifunctional, targeted, and responsive nanoplatforms [92,148]

Its control by mTORC1, calcineurin, and Akt integrates nutrient sensing with cellular quality control mechanisms

or (c) anticatalase gene transduction or Aldh2 gene overexpression (Quintanilla et al., 2012

4-37A, B )