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GIP activation may additionally potentiate the insulin secretion effects of GLP-1 activation on the pancreas and the weight loss effects of GLP-1 activation on CNS [13]

Comparison with other studies Although pharmacovigilance studies have found increased reporting rates for thyroid cancer with GLP1 receptor agonists,23 disproportionality analyses are designed to detect potential safety signals but are not intended to make causal conclusions

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[DOI] [PubMed] [Google Scholar] 117.Dineen L., Law C., Scher R., Pyon E

[DOI] [PMC free article] [PubMed] 135.Roberts ET, et al

While the exclusion of weight management treatment may limit reimbursement of GLP-1s, non-obesity/overweight diseases such as diabetes mellitus and certain cardiovascular conditions may be eligible for reimbursement because these indications are not excluded