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This chronic inflammatory response involves the activation of the microglia and astrocytes and the release of pro-inflammatory cytokines and chemokines in the CNS [137, 138]

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220 This may be due to a marked increase in the activity of arginase induced by IL-4 and IL-13 and a marked increase in the downstream product putreamine in allergen-stimulated lungs

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doi: 10.3389/fimmu.2024.1277074 119

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Effect sizes are small (Proksch et al

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