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doi: 10.1080/15548627.2021.1962682 96 GyeongmiKSe-KyeongJYu JinKHyeon-OkJSeungheeBJungilHet al

These compounds bind to NCOA4, disrupting its interaction with FTH1 and inhibiting NCOA4-dependent ferritin autophagy, thereby reducing intracellular free iron (Fe 2 ) levels and suppressing ferroptosis ( 4.2 Lipid peroxidation-related biomarkers and OA 4.2.1 Malondialdehyde (MDA) and 4-Hydroxynonenal (4-HNE) MDA and 4-HNE are key end products of lipid peroxidation and significant markers of ferroptosis

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Mitochondria and cancer

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