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Neurosci Lett (2006) 398:2159.10.1016/j.neulet.2005.12.085 230 Machado-VieiraRDietrichMOLekeRCereserVHZanattoVKapczinskiFet alDecreased plasma brain derived neurotrophic factor levels in unmedicated bipolar patients during manic episode

While short-term increases in cortisol support adaptive energy regulation, chronic elevationsespecially from prolonged or frequent fastingmay promote muscle catabolism, reduce metabolic health, and impair insulin sensitivity [44]