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Cancer and Inflammation Chronic inflammation and oxidative stress have been implicated in most of the chronic diseases of older humans, such as type II diabetes, arteriosclerosis, and cancer

In one illustrative, but non-limiting embodiment, the signaling domain of CD3-zeta is encoded by a nucleic acid that comprises or consists of the sequence AGAGTGAAGT TCAGCAGGAG CGC AGACGCC CCCGCGT AC A AGC AGGGCC A GAACC AGCTC T ATAACGAGC TCAATCTAGG AC G A AG AG AG GAGT AC GATG TTTTGGACAA GAGACGTGGC CGGGACCCTG AGATGGGGGG AAAGCCGAGA AGGAAGAACC CTCAGGAAGG CCTGTACAAT GAACTGCAGA AAGATAAGAT GGCGGAGGCC TACAGTGAGA TTGGGATGAA AGGCGAGCGC (SEQ ID NO:81)

In addition, flanking regions of the trigger RNA, visualized as described below using low-pass filtering and three-dimensional (3D) variability analysis, wrap around the ZSWIM8 clamp and bind positively charged surfaces on ZSWIM8

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Hypokalaemia (low potassium) is a recognised cause of cardiac arrhythmias and is of particular concern in individuals following very low calorie diets or those misusing laxatives or diuretics