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Janus Kinase Inhibitors Janus kinases (JAK) like JAK1, JAK2, and TYK2 (tyrosine kinase 2) are a class of cytoplasmic tyrosine kinases that contribute to cytokine-mediated signal transduction via the JAK/STAT (JAK/signal transducer and activating protein) pathway

In dendrites of cortical pyramidal neurons lacking a novel MAM protein PDZ domain-containing protein 8, a significant fraction of Ca 2+ released from the ER during synaptic stimulation accumulates in the cytosol and elevates the local dendritic Ca 2+ levels

EBioMedicine 49:318330

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Since Lp(a)-associated cholesterol will be measured as part of LDL-c there is international guidance suggesting an LDL-c correction factor should be used for those with suspected or known raised Lp(a)