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doi:10.1007/s00394-019-01998-3 Shea MK, Barger K, Booth SL, et al

Competing interests The authors declare no competing interests

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Early studies from the late 1990s reported that supplementation at 12 grams per day improved mood and reduced fatigue in patients with major depressive disorder, as evidenced by reductions in Hamilton Depression Rating Scale scores by about 2030% over 48 weeks [5]

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In the multivariate analysis, l-carnitine administration (odds ratio [OR] 3.51, 95% confidence interval [CI] 1.239.99, p = 0.019) and baseline NIRS data of 0.07 mMmm (OR 5.21, 95% CI 1.6916.0, p = 0.0041) were found as independent significant factors