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Specifically, copper participates in regulating several fundamental cellular processes, such as mitochondrial respiration, antioxidant defense, and the biosynthesis of hormones, neurotransmitters, and pigments (Lippard and Berg, 1994

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Besides our data showing Nrf2 levels decline by 75% in the AD cortex but not cerebellum, previous work from coauthors showed decline of Nrf2 mediated antioxidant defenses in aging mouse cerebellum 86,87

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For instance, it has been demonstrated that MitoQ functions by restoring mitophagy in tubular cells through Nrf2-mediated regulation of PTEN-induced putative kinase 1(PINK) transcription, thereby ameliorating mitochondrial oxidative stress and abnormal mitochondrial dynamics [216]