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In addition to genetic disease-risks, the identification of genetic disease-modifiers associated with disease complications, severity or prognosis provides crucial insights into the biological processes implicated in disease progression

[DOI] [PMC free article] [PubMed] [Google Scholar] 108.Zhang X., Zhou C., Chen G., Li Y., Liu X., Luo S

GH and IGF-1 roles in the regulation of the osteoblast (OB) lineage: Activation of the IGF-1R on MSCs triggers signaling cascades that lead to increased expression of the Runx2

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Gen Comp Endocrinol 96:1218 Hu SD, He WL, Wu G (2021) Hydroxyproline in animal metabolism, nutrition, and cell signaling