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The effect of Pycnogenol on the microcirculation, platelet function and ischaemic myocardium in patients with coronary artery diseases

This increase in insulin sensitivity will reduce the mandatory dose of insulin for proper glycemic control

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However, it exhibits low cell membrane permeability and demonstrates substantial toxicity in animal models, thereby constraining its potential application as a therapeutic agent (Zweygarth et al., 1986)

582,583,584 Catecholamines can induce glycogenolysis by activating glycogen phosphorylase (GP) and enhance gluconeogenesis by activating fructose-1,6-bisphosphatase (FBPase) to increase fructose-6-phosphate levels and PEPCK to promote the synthesis of phosphoenolpyruvate