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[38] It added, "heavy regulation by restricting access to e-cigarettes would just encourage continuing use of much unhealthier tobacco smoking." [38] A 2014 review said regulation of the e-cigarette should be considered on the basis of reported adverse health effects

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[4] Article 2.2 of the Agreement on Technical Barriers to Trade (TBT Agreement)

In addition, smoking has been associated with higher rates of opioid dependence, alcohol dependence and other substance use disorders