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We know that clogged coronary arteries can lead to heart attacks

Increased mitochondrial biogenesis improves muscle oxidative capacity, promoting ATP production through oxidative phosphorylation and optimizing the use of glucose and fatty acids as fuel

Bibcode:1946JAChS..68.1009P

For endurance sports such as swimming, triathlons, marathons, skiing, and cycling, success depends not only on the athletes cardiovascular and muscular capacities but also on their energy metabolism (Li et al

It is also suggested that during times of stress, such as when dieting and training hard, the body's ability to produce its own tyrosine from the amino acid phenylalanine is compromised

PDR for Nutritional Supplements