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While the Phase 2 trial did not specifically stratify outcomes by baseline eGFR, GLP-1 receptor agonists as a class have demonstrated renoprotective effects in at-risk populations

Treated animals show increased oxygen consumption and energy expenditure measured by indirect calorimetry, confirming enhanced metabolic rate

10.1038/nrdp.2017.40 [DOI] [PubMed] [Google Scholar] Higgins J., Green S

The nausea from oral semaglutide tends to be more frequent than from the injectable form because of higher local concentrations in the GI tract

It is not FDA-approved for human therapeutic use, and most evidence involves preclinical studies, animal models, and limited early human safety data

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