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doi: 10.1097/CLD.0000000000000116, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 30.Tapper EB, Salim N, Baki J, Zhao Z, Sundaram V, Patwardhan V, et al
Brain Res 951:330335 Waniewski RA, Martin DL (1998) Preferential utilization of acetate by astrocytes is attributable to transport

A 2011 systematic review of clinical data suggested that citicoline could hasten the resorption of cerebral edema and improve the recovery of consciousness and neurologic disorders in severe TBI cases (classified by Glasgow Coma Scale [GCS] scores of 8) (5)

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Additionally, at least five ancillary symptoms must be present, such as limb heaviness or generalized weakness, diminished concentration, or attention, decreased motivation or interest in usual activities, insomnia or hypersomnia, nonrestorative sleep, perceived need to struggle against inactivity, pronounced emotional response to fatigue, perceived short-term memory issues, or prolonged malaise following exertion (11)
Later, the safety and efficacy of acetyl-l-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy was analysed in a double-blind, parallel-group, placebo-controlled, multicentre trial of 90 patients
