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A medical professional can assess potential drug interactions, screen for the risk of pancreatitis, check kidney function, and guide dose adjustments as needed

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Both medications carry the same boxed warnings

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Niacin, particularly at pharmacologic doses, can impair insulin sensitivity and increase hepatic glucose production, potentially raising blood glucose levels

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Unmeasured confounders, particularly lifestyle factors such as dietary patterns, physical activity levels, smoking status, and alcohol consumption, could influence both treatment selection and observed ocular outcomes

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They correlate with dose week, meal composition, hydration, sleep, and alcohol

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