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Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

The kidneys normally degrade roughly one-third of circulating insulin, so progressive renal impairment prolongs the half-life of these medications

Oncotarget 7 , 4808148092 (2016)

Because the SECIS element is located in the 3 UTR in eukaryotes, not in the coding region as in prokaryotes, it obviates the need for dissociation and reassociation of the SECIS-SBP2 complex with each incorporation cycle

The completion of GSH synthesis is catalyzed by glutathione synthetase (GS), in a reaction in which -glutamyl-cysteine is covalently linked to glycine ( Figure 1 )

albicans Emerging therapeutic approaches show great translational potential for overcoming existing bottlenecks