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Bad kidney function can cause too much B12 to build up, leading to problems

Targeting cell senescence and senolytics: novel interventions for age-related endocrine dysfunction

After a single intravenous (IV) administration, single intramuscular (IM) administrations at three doses in successive increments along with repeated IM administrations, the elimination half-life (t 1/2 ) of prototype BPC157 was less than 30 min, and BPC157 showed linear pharmacokinetic characteristics in rats and beagle dogs at all doses

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73 also observed that injection of recombinant GDF11 protein into older rats significantly hindered muscle regeneration and function and induced tissue fibrosis

Also, protein adduct levels tend to peak at later time points in humans [18] when compared to mice [15], which correlates with the delayed cell injury in patients and human hepatocytes