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[DOI] [PubMed] [Google Scholar] 22.Braffett B.H., Gubitosi-Klug R.A., Albers J.W., Feldman E.L., Martin C.L., White N.H., Orchard T.J., Lopes-Virella M., Lachin J.M., Pop-Busui R., et al

The truncation dramatically reduces binding to IGF binding proteins (IGFBPs), increases receptor affinity, and shortens half-lifecreating a potent, rapidly-acting growth factor with predominantly local rather than systemic effects when administered

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Hwang Is, Lee J, Hwang JH, Kim KJ, Lee DG

Xue HY, Gao GZ, Lin QY, Jin LJ, Xu YP

The conservation of these structural motifs across insect taxa suggests evolutionary constraints linked to essential functions
