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Moreover, Hcy has been shown to enhance the expression of methylase and upregulate the methylation of glutathione peroxidase 4 (GPX4), thereby inducing oxidative stress and ferroptosis in the nucleus pulposusa phenomenon that warrants further investigation [50,51,52]

Among all the NOXs, DUOX and NOX-4 primarily generate H 2 O 2 , while the others mainly generate superoxide [18, 19]

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Molecular mechanism for the red blood cell senescence clock

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However, the proof of concept is based on the analysis of causal effects due to ectopic overexpression of NAMPT in cells