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doi:10.1016/j.jcmg.2022.06.018 Khan SS, Matsushita K, Sang Y, et al

No dose-response studies exist examining skin brightening efficacy across different dosage levels

Thus, bioaccessibility is defined as the maximum concentration soluble in the simulated gastrointestinal environment that is available for further absorption processes into the intestinal mucosa (Costa et al., 2022)

Quantitative PCR was performed with a Luna Universal One-Step RT-qPCR Kit (New England Biolabs Inc., Ipswich, MA, USA) using the ABI Prism 7000 detection system (Applied Biosystems, Waltham, MA, USA)

With respect to structural outcomes, the guideline development group regarded measurement of joint space narrowing as of questionable value in assessing any potential beneficial structural modification, and convincing evidence of improvement in patient-centred outcomes consequent on any structural modification was still lacking