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These findings suggest possible metabolic activity in clinical settings, though broader interpretation requires caution

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This makes the problem of hypersensitivity to vitamin B12 so important that, in addition to standard solutions, such as vitamin B12 injections with premedication [81], attempts are made to desensitize patients who require constant supplementation with this vitamin, and these actions seem to bring the expected results [9,10,11,12,13,14]