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discussion 61
Lipids 2014, 1841 (3), 314318

ShirasebFMirzababaeiADaneshzadEKhosraviniaDClarkCCTMirzaeiKet al

2021;7:eabi8193

This represents direct evidence of the mechanism at the cellular level, though its translation to clinical longevity outcomes in humans continues to be studied

Simultaneously, the un-recycled homocysteine begins to accumulate rapidly, driving up systemic inflammation and oxidative stress