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doi:10.1136/jcp.2007.050054
Activation of PGC-1 in muscle cells not only promotes mitochondrial biogenesis and enhances metabolic efficiency but also influences the expression of FNDC5, thereby controlling irisin release [60,89]
Its ability to stimulate GH and IGF-1 release and modulate various physiological processes makes it invaluable for studying endocrine regulation, metabolism, muscle growth, bone health, and cognitive function
These results indicated that reduced heteroplasmy leads to greater upregulation of mtDNA translation and that levels of heteroplasmy correlate to mtDNA copy number, glucose metabolism, and mitochondrial functions when normalized to mtDNA:nDNA copy number
Similarly, in cases of cerebral ischemia, VC demonstrates protective effects against brain tissue injury [138]
