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Notably, increased NAD+ levels also activate NAD+dependent signaling pathways such as sirtuins (SIRT1/SIRT3), further enhancing mitochondrial biogenesis and energy metabolism

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doi: 10.1016/j.coi.2009.03.001 28 LangrishCLChenYBlumenscheinWMMattsonJBashamBSedgwickJDet al