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Historical studies utilized specific, moderate amounts rather than high doses, and exceeding these parameters has no documented clinical backing

Protection against UVB inactivation ( in vitro ) of rat lens enzymes by natural antioxidants

doi: 10.1093/toxsci/kfi211

National Library of Medicine) without a limiting period, although particularly focusing on reports published in the last decade

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Roh's group found a lead compound ( 120 , Figure 24 ) with a thiazolidine-2,4-dione skeleton and its potential in the inhibition of IKK (IC 50 = 1500 nM), therefore, they tried to optimize this core via exploring the electron push-pull effect of the right moiety and analyze the SAR [194]