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Description
Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs
10.1212/WNL.0000000000006926 43 FanibundaS

Hyperglycemia stimulates the proliferation of vascular smooth muscle cells and collagen synthesis, leading to fibrosis and hardening of the vascular wall, causing blood vessels to lose their elasticity, increasing vascular resistance and pressure, and inducing diabetic cardiovascular disease
Neither of those is the same as the regulator accepting a NAM-only package in place of animal data

Anderson C, Boehme S, Ouellette J et al
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