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JW: Conceptualization, Writing original draft

For example, are studied as markers for degradation and repair processes factors like neutrophil elastase (NE) or matrix metalloproteases (MMP), which are detectable in bronchoalveolar lavage fluid (BALF) or sputum [53]

7.4 Alkaloids: suppressors of apoptosis and metabolic dysfunction Alkaloids attenuate ALD by suppressing the MAPK/NF-B axis, thereby reducing ERK/JNK phosphorylation and TNF- production, which mitigates hepatocyte apoptosis ( Oxymatrine, a quinolizidine alkaloid from the roots of Sophora flavescens Aiton [Fabaceae], inhibits ERK1/2-mediated apoptosis and downregulates pro-inflammatory cytokines ( Berberine, an isoquinoline alkaloid from traditional Chinese medicinal herbs such as Coptis chinensis Franch

This hereditary condition impedes the ileum (the final section of the small intestine) from effectively binding and transporting cobalamin into the bloodstream

Pan-inhibition of protein disulfide isomerase caused cell death through disrupting cellular proteostasis in pancreatic ductal adenocarcinoma cells

When combined with anti-PD-1 therapy, this approach completely eradicated microsatellite instability-high (MSI-high) tumors and significantly reduced the size of microsatellite stable (MSS) tumors (74)