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Glyburide, a sulfonylurea-containing diabetic drug known to inhibit ATP-sensitive K + - channels in the pancreas, also impedes NLRP3-activation and IL-1 production at micromolar concentrations upstream of inflammasome assembly and independent of effects on K + channels [99]

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Chronic inflammation, immune exhaustion, and the presence of latent viral reservoirs in PWH make them less tolerant to cellular or genetic engineering interventions, increasing the risk of immune-related adverse events