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A first-in-human phase I study of the anticancer stem cell agent ipafricept (OMP-54F28), a decoy receptor for Wnt ligands, in patients with advanced solid tumors

Furthermore, the simultaneous mutation of all six phospho-sites to alanine was required to inhibit LRRK2-mediated ArfGAP1 phosphorylation, suggesting that none of these six residues serve as a dominant phospho-site (Xiong et al., 2012)

[DOI] [PubMed] [Google Scholar] 88.Varvel N.H., Grathwohl S.A., Baumann F., Liebig C., Bosch A., Brawek B., Thal D.R., Charo I.F., Heppner F.L., Aguzzi A., Garaschuk O., Ransohoff R.M., Jucker M

The LDH-deficient HepG2 cell line was reported previously 11

[10] Due to the potential for harmful drug interactions and other serious adverse effects, oral ketoconazole should only be used to treat serious fungal infections when no other antifungal therapies are available

Interestingly, our analyses revealed that, compared with vehicle-gavaged control mice, TFEB nuclear content was elevated in livers of acutely-treated, ethanol- gavaged mice