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For long-term knee osteoarthritis, oral collagen peptides (3-5g daily) have stronger randomized controlled trial support across multiple studies totaling 507 patients

Lippman, S

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[PubMed] [Google Scholar] [38].Miller JC, Thomson CD, Williams SM, van Havre N, Wilkins GT, Morison IM, Ludgate JL, Skeaff CM, Influence of the glutathione peroxidase 1 Pro200Leu polymorphism on the response of glutathione peroxidase activity to selenium supplementation: a randomized controlled trial