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Stacking multiple GLP-1 agonists together, such as semaglutide and tirzepatide, is generally not recommended due to overlapping mechanisms and increased side effect risk

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Interestingly, ABHD5 mutations causative in CDS do not co-localize to LDs and are unable to stimulate PNPLA2 lipolytic activity (30), demonstrating an important function for the interaction in the etiology of CDS and lipid storage

Nutritional Deficiencies : Poor dietary intake or restrictive dieting can lead to insufficient levels of iron, Vitamin B12, folate, and protein

B12 is present in a variety of food sources (mainly animal-based products), where it is bound to protein molecules

[2] Additionally, GLP-1 agonists may be prescribed for individuals with type 2 diabetes who have coexisting conditions such as atherosclerosis, heart failure, or chronic kidney disease, as these medications have demonstrated potential benefits beyond glycemic control