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An advanced design adds active tumor-targeting agents on the surfaces of LNPs that can target (i) the tumor cell surface, (ii) the tumor extracellular matrix and (iii) the endothelial cell surface receptors of tumor vessels by biological or chemical means

A casecontrol study that included 67 PD patients compared to 24 healthy controls showed that plasma levels of -synuclein, NLRP3 inflammasome, caspase-1, and IL-1 increased in PD patients compared to healthy patients controls (Fan et al

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Dexmedetomidine reversed hypoxia/reoxygenation injury-induced oxidative stress and endoplasmic reticulum stress-dependent apoptosis of cardiomyocytes via SIRT1/CHOP signaling pathway

Within the OL lineage, CPZ uniquely induces a strongly dysregulated DAO state, marked by the expression of Cdkn1a and Nupr1 , while both models converge on a similar remyelination state characterized by immune gene upregulation, including Socs3 and B2m