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NAC Administration Ameliorates TNBS plus Ethanol Induced Mucosal Injury To test whether the early TNBS+ethanol-induced GSH depletion was important for the development of colitis by rendering mucosa susceptible to the TNBS+ethanol-induced ROS overgeneration, we examined the effect of NAC, a GSH precursor, on both mucosal GSH content and extent of injury in TNBS+ethanol-treated rats

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The mechanisms by which zinc protects the blood vessels include the regulation of Nrf2, a transcription factor important for the expression of genes encoding antioxidant enzymes and for the induction and expression of metallothionein [32,33,34]

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Upregulation of critical lineage markers associated with change from glycolytic CD14 + precursors to mitochondrial metabolism during initial 24 h of GM-CSF/IL4 differentiation, which persisted across DC stages reaching 86% in mDC