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There is usually a delay before enzyme activity increases

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In this scenario, as juveniles are exposed to physical, chemical, and biological factors, tissue ischemia may neutralize the cofactors of antioxidant enzymes, such as superoxide dismutase and NADPH oxidase myeloperoxidase, preventing return to the body homeostasis (Camini et al

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Many studies are short-term, involve small sample sizes, or focus on specific breeds under controlled experimental conditions, which limits the generalizability of findings to the broader canine population

in ( f-j ) two-tailed p values were determined by unpaired t -test