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Altogether our results demonstrate that GSTP1/2 are a critical regulators of hepatocyte proliferation in the initial phases of liver regeneration

Although MTHFR deletion in the F1 generation has little effect on sperm count and testicular weight, the adverse effects are further aggravated in the F2 generation, resulting in the adverse phenotype of F2 MTHFR deficient males (12)

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This can lead to liver failure, renal failure, pancreatitis, brain dysfunction, coma, and even death [57]