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This provides an important tool for research into aging-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, and offers experimental evidence for intervention strategies in neuronal aging

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10.1136/jcp-2023-209005 [DOI] [PMC free article] [PubMed] [Google Scholar] Murga M, Jaco I, Fan Y, Soria R, Martinez-Pastor B, Cuadrado M, Yang S, Blasco MA, Skoultchi AI, Fernandez-Capetillo O (2007) Global chromatin compaction limits the strength of the DNA damage response

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The authors showed also that miR-939 overexpression downregulated PI3K-AKT pathway downstream the IGF1R and the restoration of miR-939 could represent a potential therapeutic approach for patients with osteosarcoma following the purpose of a miRNA-based targeted anticancer therapy
