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Francescone RB, Vendramini-Costa D, Franco-Barraza J, Wagner J, Muir A,Lau AN,Gabitova L, Pazina T,Gupta S, Luong TRDMalik R,Thapa RJ,Restifo D,Zhou Y,Cai KQ,Hensley HH,Tan Y,Kruger WD,Devarajan K, Balachandran S, Klein-Szanto AJ, Wang H, El-Deiry WS

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Anti-inflammatory effects of FGF-21 further contribute to its neuroprotection

Less common is the methylation of guanine and adenine with the formation of 7-methylguanine and 3-methyladenine, respectively

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However, the duration of the hormone signal is short, as cAMP is quickly deactivated by the enzyme phosphodiesterase (PDE) , which is located in the cytosol