glutathione transferase mechanism of action Overexpression S-Transferases in Human Diseases: Drug Targets and Therapeutic Implications Glutathione transferases as mediators of

Dutton DJ, Fyie K, Faris P, Brunel L, Emery JH

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Disulfiram, which was originally used as an antialcoholism drug, has been repurposed to inhibit ALDH and disrupt redox balance in CSCs, leading to increased sensitivity to chemotherapy and radiotherapy

Lessons from arthritis and cell therapy in cancer patients point to therapy for severe disease

Mechanistically, p53 suppresses the production of NADPH by inhibiting malic enzymes and G6PD, as well as the associated pentose phosphate pathway

doi: 10.1016/S0300-483X(01)00471-1