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144 , 145 Endogenous diseaseproduced IgG, in particular the IgG type Mprotein, may compete with CD38 mAbs for FcRn, potentially leading to a shorter halflife for the therapeutic IgG, although this has not been shown clinically

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The carboxy-terminal of occludin contains the binding site for zonula occludens (ZO)-1

Li et al., 2025)

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The Bottom Line While Mounjaro is proving to be a game changer in treating type 2 diabetes and obesity, this drug comes with a considerable list of side effects