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Exhibit 4-3 Contribution margin income statement and video explanation Video Illustration 4-4 : Using CVP to show the effects on net operating income from changes in variable costs Lo3 Refer to the original in Exhibit 4-4

Retatrutide has one of the longest plasma half-lives on this peptide half-life chart at approximately 6 days, followed closely by Semaglutide at roughly 7 days and Tirzepatide at about 5 days

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Elevated IGF-1 levels have been associated with increased risk of certain cancers, fluid retention, and joint pain

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This figure was sometimes interpreted in the Middle Ages as a symbol of Christs union of divine and human natures (D = Dio = God
