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Separate-vial workflow Staggered Co-Titration - Two Vials, Two Schedules Run retatrutide alone for 8 weeks, then add cagrilintide at the lowest dose
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Such a design would require that medications be gradually reduced and discontinued prior to randomization
The first 8-12 weeks are where the majority of discomfort happens, and it fades from there
Pediatr Res (1993) 34:6425
