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doi: 10.1016/j.clinre.2021.101781

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EClinicalMedicine , 73 FDA Approves New Medication for Chronic Weight Management

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However, the depolarizing effect in the hypocretin (Orexin-A)-releasing neurons can be suppressed by glutamate and GABA receptor blockers [96], suggesting the participation of G-proteins rather than a direct effect on N av channels [98] by GLP-1R agonists