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Description
Low expression levels of CISD1 and CISD2 limit the Fe 3+ content in mitochondria, thereby inhibiting ferroptosis

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10.3389/fendo.2020.00025 116 SinopoliA.MagrA.MilardiD.PappalardoM.PucciP.FlagielloA.et al (2014)

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Therefore, in addition to reducing the oxidative stress generated by free radicals, HK-2 synthesizes bioactive transition metals, including Fe 2+ , thus reducing the availability of these ions for Fenton reactions, which produce highly toxic hydroxyl radicals [156]

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