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For instance, mephedrone increases both dopamine and serotonin release, whereas -PVP primarily targets dopamine and norepinephrine transporters ( 4.2 Oxidative stress and mitochondrial dysfunction The excessive release of monoamines promotes ROS formation through the auto-oxidation of dopamine and norepinephrine

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Additional intracellular stressors, such as phagosome acidification and nutrient deprivation, also contribute to tolerance 10

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