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Free radicals are produced by the body in response to stress, pollution, and UV radiation

, IL-6, IL-1, TNF-, and PGE2 )and serum lipopolysaccharides levels [216,217,218,219,220] and disrupting the intestinal environment, including reducing the diversity of intestinal microorganisms [216, 217] and fecal SCFAs [216, 217, 221], and regulating intestinal PH value [221] and oxidative stress through glycoxidation (NO, protein carbonyl (PCO), MPO and alkaline phosphatase (ALP)) [220, 221]

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Role of corticotropin-releasing factor signaling in stress-related alterations of colonic motility and hyperalgesia

Prabhakar K, Muzammil Afzal S, Surender G, Kishan V (2013) Tween 80 containing lipid nanoemulsions for delivery of indinavir to brain

Trypsin from pancreatic juice hydrolyzes the cobalophilin, releasing the vitamin, which then attaches to the castles intrinsic factor