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Future perspectives Potential difficulties in many clinical trials investigating PIPN prevention include small sample sizes, the absence of placebo control groups, varying dosing and treatment regimens of investigational medications, non-standardized definitions and assessments of neuropathy, and inclusion of cancer patients receiving different chemotherapy treatment protocols

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doi: 10.1016/j.cell.2012.03.042

And their health is a wreck and theyre not really going to make it to where they think maybe theyre on the path to