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This can further jeopardize antioxidant defense and contribute to injury

Metformin is known to impact cellular levels of NAD + , ATP, and tricarboxylic acid intermediates, as well as AMPK, which affect epigenome modification enzyme activity [166]

This is because melanin production resumes once glutathione levels drop in the body

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Current research employs different types of solvents used (e.g., methanol, acetone, ethanol, and dichloromethane), extraction conditions (e.g., temperature, time, and solvent-to-material ratio), and preparation techniques, making it difficult to compare results or replicate outcomes in real-world settings