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This treatment enhanced the vasculogenesis in a glioma stem cell-dependent manner as evidenced by the elevated expression of CD34 + CD31 + vessel-like structures and an increased abundance of CD133 + CD34 + cells within the tumour core and also facilitated the glioma cells to transdifferentiate into endothelial phenotype [237]

Mouzat et al., 2019)

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Lysosome purification from two independent knockout colonies revealed that significant fractions of GNPT and LYSET were mislocalized to the lysosome and partially degraded (Fig